Dilute Insulin Publications

Young children with a low total daily dose (TDD) might benefit from dilute insulin.

CamAPS FX is CE marked for use from 5 to 350 insulin units per day, however it may be worth considering diluting insulin if TDD is below 8 units per day and especially in those newly diagnosed and likely to honeymoon.

ISPAD Chapter 9: Insulin Treatment in Children and Adolescence with Diabetes

Point 17: Insulin Concentrations

  • The most widely available insulin concentration is 100 IU/mL (U 100).
  • Treatment with U 40 (40 IU/mL), U50 or other concentrations such as U500 is also acceptable, subject to availability and special needs.
  • Care must be taken to ensure that the same concentration is supplied each time new supplies are received.
  • Very young children occasionally require insulin diluted with diluent obtained from the manufacturer, but special care is needed in dilution and drawing up the insulin into the syringe.
  • Rapid-acting insulin can be diluted to U10 or U50 with sterile NPH diluent and stored for 1 month for use in pumps for infants or very young children.

Read more:

Elleri 2014 Overnight Closedloop In Young Children Dilute Vs Std Insulin [571.81 KB]

ISPAD Consensus 2017 Managing Diabetes In Preschool Children [1.82 MB]

ISPAD Guidelines 2018 Chapter 9 Insulin Treatment [2.21 MB]

Ruan 2015 Pharmacokinetics Of Diluted U20 Insulin [257.53 KB]